PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) and PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) are conditions that affect children and adolescents. Both involve a sudden, dramatic onset of neuropsychiatric symptoms such as obsessive-compulsive disorder (OCD), tics, severe anxiety, mood changes, or behavioral regression.
PANDAS is specifically linked to a strep infection triggering an abnormal immune response that mistakenly attacks brain tissue.
PANS is a broader category where the immune system is activated by other infections, metabolic issues, or environmental triggers, not just strep.
The hallmark of both is abrupt symptom onset, often overnight, in a child who was previously developing normally. Parents frequently describe their child as “suddenly different,” with changes in personality, behavior, and functioning.
At Aven Clinic, we recognize how frightening and disruptive PANS and PANDAS can be for families. Our approach focuses on identifying the underlying triggers, calming immune system dysfunction, and supporting neurological healing for long-term recovery.
Both PANS and PANDAS result from a misdirected immune response that affects the brain, particularly areas involved in movement, mood, and behavior.
In PANDAS, a recent strep infection leads the immune system to produce antibodies. These antibodies mistakenly attack parts of the brain (basal ganglia), causing OCD-like behaviors, tics, and emotional changes.
PANS may be triggered by infections beyond strep, including:
- Mycoplasma pneumoniae
- Influenza
- Lyme disease and other tick-borne infections
- Viral infections like Epstein-Barr virus (EBV)
Toxins, nutritional deficiencies, or metabolic dysfunctions may contribute to onset or worsen symptoms.
Underlying immune system imbalances make children more vulnerable to inappropriate inflammatory responses.
Family history of autoimmune conditions or psychiatric disorders may increase risk.
The common thread is an inflammatory response targeting the brain, disrupting normal neurological and emotional regulation.
The hallmark of both PANS and PANDAS is sudden, dramatic onset of symptoms that seem to appear overnight or within a few days.
Additional Symptoms
Behavioral regression (sudden loss of age-appropriate skills)
Academic decline due to attention and memory issues
Sensory sensitivities (light, sound, textures)
Restricted eating or food refusal
Urinary frequency or bedwetting
Sleep disturbances and insomnia
Sudden separation anxiety or clinginess
Core Symptoms
Obsessive-Compulsive Behaviors (OCD): Rituals, compulsions, intrusive thoughts
Motor or Vocal Tics: Sudden, repetitive movements or sounds
Severe Anxiety or Panic Attacks: Often without clear triggers
Mood Swings or Depression: Rapid emotional changes, irritability, or sadness
Parents often describe the change as sudden and extreme, unlike gradual development of typical psychiatric disorders.
Treatment must address both the immune dysfunction and the resulting neuropsychiatric symptoms. At Aven Clinic, we use a personalized, integrative approach to help children recover fully and restore balance.
Treat the Trigger
Antibiotics: If strep or another bacterial infection is identified, targeted antibiotics may be prescribed.
Antivirals or Antiparasitics: For viral or tick-borne triggers such as Lyme disease.
Support Neurological Healing
IV Nutritional Therapy: Provides key nutrients and antioxidants to support brain repair.
Targeted Supplements: Omega-3s, B-vitamins, magnesium, and glutathione for neurological health.
Hormone & Adrenal Support: Balancing stress response to reduce flare-ups.
Long-Term Resilience
Gut Health Support: Probiotics and nutrition to strengthen immunity.
Lifestyle Interventions: Rest, stress management, and structured routines.
Ongoing Monitoring: Early detection of relapses or new triggers ensures faster intervention.
Calm the Immune Response
Anti-inflammatory Therapies: NSAIDs, steroids (in acute cases), or natural anti-inflammatories.
IV Immunoglobulin (IVIG): For severe cases, IVIG can help reset immune function.
Peptide Therapy: Supports immune regulation and reduces inappropriate inflammation.
Address Behavioral & Emotional Symptoms
Cognitive Behavioral Therapy (CBT): Helps children cope with OCD and anxiety.
Family Support & Counseling: Empowers parents with strategies to manage sudden behavioral changes.
School Accommodations: Academic adjustments may be needed during recovery.
PANS and PANDAS can be overwhelming for families due to their sudden onset and dramatic symptoms. But with the right evaluation and comprehensive care, recovery is possible. Addressing both the infection triggers and the immune dysfunction offers children the best chance to regain balance, function, and quality of life.
At Aven Clinic, we help families facing PANS & PANDAS:
by treating infections and reducing inflammation
in the immune and neurological systems
with long-term support for growth and development
📅 Schedule your consultation today and take the first step toward restoring your child’s health and peace of mind.
